Cell Mediated Immune Response

Immunopharmacology of Macrophages and Other Antigen-Presenting Cells

The consequences for diseases involving the immune system such as AIDS, cell mediated immune response and chronic inflammatory diseases such as bronchial asthma, rheumatoid arthritis, cell mediated immune response and atherosclerosis, now account for a considerable economic burden to governments worldwide. In response there has been an enormous research effort investigating the basic mechanisms underlying such diseases, cell mediated immune response and a tremendous drive to identify novel therapeutic applications for their prevention cell mediated immune response and treatment. Though a plethora of immunological studies have been published in recent years, little has been written about the implications of such research for drug development. As a consequence, this area has not gained the prominence of other new fields such as molecular pharmacology or neuropharmacology, cell mediated immune response and a focal information source for the many pharmacologists interested in diseases of the immune system remains unpublished. The Handbook of Immunopharmacology Series provides such a source through the commissioning of a comprehensive collection of volumes on all aspects of immunopharmacology. Editors have been sought after for each volume who are not only active in their respective areas of expertise, but who also have a distinctly "pharmacological bias to their research. The Series follows three main themes, each represented by volumes on individual component topics. The first covers each of the major cell types cell mediated immune response and classes of inflammatory mediators ("cells cell mediated immune response and mediators"). The second covers each of the major organ systems cell mediated immune response and the diseases involving the immune cell mediated immune response and inflammatory responses that can affect them ("systems"). The third covers different classes of drugs currently used to treat these diseases as well as those underdevelopment ("drugs").
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Cell-mediated immunity - Cell-mediated immunity is an immune response that does not involve antibodies but rather involves the activation of macrophages and natural killer cells, the production of antigen-specific cytotoxic T-lymphocytes, and the release of various cytokines in response to an antigen. Cellular immunity protects the body by:

B cell - B cells are lymphocytes that play a large role in the humoral immune response (as opposed to the cell-mediated immune response).

T cell - T cells are a subset of lymphocytes that play a large role in the immune response. The abbreviation "T" stands for thymus, the organ in which their final stage of development occurs.

Cytokine - Cytokines are small protein molecules that regulate communication among immune system cells and between immune cells and those of other tissue types. These chemicals are actively secreted by immune cells as well as other cell types in response to external stimuli.

cellmediatedimmuneresponse

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